Haptoglobin Recombinant Rabbit mAb (SDT-339-45)
SKU: 32244528371

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)

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Description

Haptoglobin Recombinant Rabbit mAb (SDT-339-45)Product Specification Host Rabbit Antigen Haptoglobin Immunogen Recombinant Protein Accession P00738 Clone Number SDT 339 45 Antibody Type Rabbit mAb Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize Hemoglobin Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rabbit
Antigen Haptoglobin
Immunogen Recombinant Protein
Accession P00738
Clone Number SDT-339-45
Antibody Type Rabbit mAb
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize Hemoglobin
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Haptoglobin, in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so-called Hp1 and Hp2, the latter one having arisen due to the partial duplication of Hp1 gene. Three genotypes of Hp, therefore, are found in humans: Hp1-1, Hp2-1, and Hp2-2. Hp of different genotypes have been shown to bind hemoglobin with different affinities, with Hp2-2 being the weakest binder. Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The HP gene encodes a preproprotein that is processed to yield both alpha and beta chains, which subsequently combines as a tetramer to produce haptoglobin. Haptoglobin functions to bind the free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.

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SKU: 32244528371

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Cheryl Askew
Boise, US
★★★★★ 5
Great book
Format: Hardcover
My 4 yr old loves it. His interest is sharks and dinosaurs
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Reviewed in the United States on January 9, 2026
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MMW
Draper, US
★★★★★ 5
great book for young children
Format: Hardcover
My 4 year grandson loves this book. He is already giving me facts on sharks.
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Reviewed in the United States on September 26, 2025
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Marissa
Carnegie, US
★★★★★ 5
Christmas Favorite!
Format: Hardcover
My 3 year old grandson loved this Christmas gift! Of all of his gifts, this one was his favorite!
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Reviewed in the United States on January 3, 2026
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Amazon Customer
Omaha, US
★★★★★ 5
Good book for my 3 yr old
Format: Hardcover
Son loves this book (3 Yrs old almost 4) . The buttons read the pages out loud.
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Reviewed in the United States on December 2, 2025
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avm
San Leandro, US
★★★★★ 3
Good informative, age-appropriate book
Format: Hardcover
Really like the book, so did the kids but 2 of the buttons did not work. Sadly, had to return.
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Reviewed in the United States on December 29, 2025

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