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Description
PTP1B Recombinant Rabbit mAb (S-R336)Product Specification Host Rabbit Antigen PTP1B Synonyms Tyrosine protein phosphatase non receptor type 1, Protein tyrosine phosphatase 1B, PTPN1 Location Endoplasmic reticulum membrane Accession P18031 Clone Number S R336 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA,
Product Specification
| Host | Rabbit |
| Antigen | PTP1B |
| Synonyms | Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTPN1 |
| Location | Endoplasmic reticulum membrane |
| Accession | P18031 |
| Clone Number | S-R336 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:250 | null |
Background
PTP1B was first isolated from a human placental protein extract, but it is expressed in many tissues. It is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B can dephosphorylate the phosphotyrosine residues of the activated insulin receptor kinase. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.
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4.3 ★★★★★
Based on 1846 reviews
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Product Reviews
★★★★★ 5
Making Friends
Format: Kindle
This whole series is absolutely fantastic. I love the idea of a magical sketchbook that Dany can draw anything in. My favorite part (and my sister’s), is when Prince Neptune acts like he’s about to leave, and he kisses Dany. Then, he tries to yank the sketchbook out of her hands and he yells “So I will reshape this world to fit my needs!” with the most evil look on his face. It’s super funny. All of the backstories were well-developed, and the Madison and Amanda storyline really impressed me! I think anyone with a good sense of humor would love this book.
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Reviewed in the United States on November 25, 2021
★★★★★ 3
Cute story about friendship with a fantastical twist.
Format: Kindle, Format: Kindle
Amazon has been recommending me this book for quite some time now, and since I read a lot of reviews saying that the premise was very interesting/ unusual, I decided to give it a shot. I bought the Kindle version.
#1 The artwork: I'm a huge fan of graphic novels, so the art on the cover caught my eye immediately. I liked the overall style, and color palette. However I feel like the interior art falls flat sometimes. No doubt that the artist knows her stuff, but I felt like sometimes she might not have had such a strong handle on the characters. The line thickness tended to vary from panel to panel on some pages, and some characters didn't always look like they belonged in the same universe.
#2: The story (spoilers): The concept for this was very interesting, and I enjoyed it for the most part, but there were some things about the story I thought were unnecessary. I don't think Prince Neptune needed to be a character at all. To me, his only real purpose was to make Danny into a less likable version of herself, and to end the book when he destroyed the school. The ending I also thought was a little weird. I had read reviews about it beforehand, but It still caught me completely off guard. I know the story is fantasy, obviously, but I think it could've been toned down just a smidge. I think if the plot focused more on the relationship between Danny, Madison, and even Danny's other friends, I would've given it five stars. I found myself asking a lot of questions about them in terms of who they were to Danny, and why it seemed like they all stopped hanging out for seemingly no reason. A point was made that Danny had a different schedule than them, but I didn't even see her make an effort to preserve her relationships despite this.
One things I really want to praise the book on however, is the humor. There was a lot of subtle jokes for older readers that I chuckled at, that would probably fly over a kid's head.
For those who are wondering, there's no swearing/ inappropriate words, but some bullying/ teasing/ crying is depicted. There is also fantasy "violence", but it's nothing worse than what you'd see in a Saturday morning cartoon on Disney channel.
#3 Final Thoughts: Overall, I would recommend this book if you have young kids interested in this kind of thing. I'm not the target demographic for this, so I'm a bit more critical, however if someone had put this in the hands of 9 year old me, I would've absolutely loved it to bits.
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Reviewed in the United States on September 10, 2020
★★★★★ 5
Definitely a win for William!
Format: Hardcover
My eight-year-old grandson read this book in a matter of days. He said it was his favorite book of all times and that now he has a favorite new author!
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Reviewed in the United States on January 18, 2026
★★★★★ 5
Recommended by 11 year old boy
Format: Hardcover
My son selected this book to read with his school instructional support as a means to mimic a high cap program. My son likes to read books on this topic, which I find a little depressing and a little dark...but listening to the thought provoking conversations that tutor and student had over ZOOM....this is highly recommended. I did not read the book, but both tutor and student enjoyed reading it. They were a little sad to move to another book. The conversations that I overhead did a wonderful job of providing historical references (which I find lacking in his schooling so far), portraying how the characters FELT, what motivated them, and in general connecting my son to a world far bigger than greater than within our Covid quarantined city. Not sure how much of this wonderful learning experience was based on the talent and experience of the tutor, but ALLIES provided content that was educational, emotional and allowed the tutor to delve deeper, connect ideas, draw inferences and start predicting outcomes. She was trying to teach him to immerse himself in the reading....not just reading for a reading log.
This was a very successful 'book club' for my son.
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Reviewed in the United States on December 16, 2020
★★★★★ 5
Great Read for 11 Year Old
Format: Hardcover
My 11 year old couldn't put this one down and was a bit sad when it ended. We've already ordered another one in the series.
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Reviewed in the United States on January 6, 2026