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Description
Nectin-1/PVRL1 Recombinant Rabbit mAb (S-279-140)Product Specification Host Rabbit Antigen Nectin 1 PVRL1 Synonyms Herpes virus entry mediator C (Herpesvirus entry mediator C; HveC), Herpesvirus Ig like receptor (HIgR), Nectin cell adhesion molecule 1, Poliovirus receptor related protein 1, CD111, PRR1 Immunogen Recombinant Protein Location Secreted, Cell membrane Accession Q15223 Clone Number S 279 140 Antibody Type Recombinant mAb Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Nectin-1/PVRL1 |
| Synonyms | Herpes virus entry mediator C (Herpesvirus entry mediator C; HveC), Herpesvirus Ig-like receptor (HIgR), Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1, CD111, PRR1 |
| Immunogen | Recombinant Protein |
| Location | Secreted, Cell membrane |
| Accession | Q15223 |
| Clone Number | S-279-140 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:200 | null |
Background
Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. PVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. The protein has been revealed as one of the key players in mediating cellular entry of the Herpes simplex virus by interacting with the viral glycoprotein D (gD).
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4.3 ★★★★★
Based on 1522 reviews
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Product Reviews
★★★★★ 5
Excellent mouse and more!
Size: One Size
The Logitech M510 wireless mouse is a very comfortable and smoothly performing mouse. It is a full size mouse that nicely fills up the palm of the hand. The weight of the mouse is "just right". The mouse body is symmetrical so that will be equally comfortable for left or right handed people.
The mouse movement and scroll wheel work perfectly smoothly with no jump or jitter. The mouse optical performance is very robust on poor surfaces. It works equally well on a mousepad, a bare table, on a pants leg, back of a book, even the palm of the hand. It tracks perfectly on almost any surface (which many other mouse brands have trouble with).
These mice use the Logitech "Unifying" USB mini receiver which can support up to six Logitech devices by itself. If you have a Logitech mouse, keyboard, trackball, etc... they can all operate from the same receiver (saves using up USB ports). Be aware that the unifying receiver ONLY works with Logitech products and that it is NOT Bluetooth or Wi-Fi. Logitech products can be "paired" with the unifying receiver in Windows and MAC (of course) and also in Linux by using the software package called "solaar" (free, open source). The mouse comes pre-paired to the receiver, so it works "out of the box". If you want to add (up to 5 more devices), you have to pair them yourself.
The battery life is awesome. Because I hate leaking batteries, I always use AA lithium cells for everything (including the mouse). My first old Logitech MS-510 mouse that I purchased over three years ago is still working fine on the FIRST batteries that I installed in it (two AA lithium). Since I use it on my desktop the mouse power switch is always left on. It must consume practically no power when not being used.
If you use the mouse with a laptop or need to move it from computer to computer, the little unifying receiver can be stored inside the mouse (in a little USB sized slot next to the batteries) to avoid losing it.
What follows is some technical information that you can skip if you don't care.
Construction: This mouse is very nicely engineered and can be completely disassembled by removing two little screws inside the battery compartment. No screws hide under the teflon slider pads, so those don't get damaged if you take the mouse apart. Every component then can be removed simply by sliding or snapping it out. Why take it apart? See next.
My personal feeling is that the left and right mouse buttons are too light (i.e. press too easily). The buttons are no lighter than other mice, I just prefer them a bit tighter. To change this, I replace the two little microswitches with Omron Series D2F-01 parts that have a 150 gf actuation force. It takes about twice the pressure to click these switches as compared to the originals. To replace them is super simple: Just unsolder the originals and solder the new ones in place. If you forget which way they go in, the orientation is printed on the PC board.
The side "scroll" buttons already use heavier pressure microswitches, so I don't change these. The "middle button" (pressing the scroll wheel) and the left/right scroll switches (rock the scroll wheel left or right) are a different type of switch that also do not need changing.
If you disassemble the mouse, be aware that the little plastic slider for the power switch will be free to fall out when the mouse PC board is removed. If you don't know this, it's possible for the slider to silently fall out, never to be seen again.
I won't tell you HOW to unsolder and resolder the button microswitches, because if you don't know how, you shouldn't be doing jt in the first place (or get an electronics-knowledgable friend to help). And, of course opening and modifying the mouse will void the warranty!
I will give you one important hint: Because the mouse was assembled using RoHS compliant lead free solder, the microswitch solder joints should first be RE-SOLDERED with leaded solder before sucking or wicking the joints clean. This is done to "alloy" the high temperature lead free solder into more manageable leaded solder to avoid burning/ruining the (single sided) PC board.
Good luck! This mouse (hacked or not) gets 5 stars and both thumbs up. It works flawlessly, it's comfortable, battery life is amazing and the price is good (even better when it's sometimes on sale). Grab one!
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Reviewed in the United States on December 27, 2020
★★★★★ 5
Excellent mouse, good size, enough buttons
Size: One Size
Easy to setup. Fit hand well. Has enough buttons to do everything I want. Good price.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
10/10 work mouse
Size: One Size
Lasts forever. Been my work mouse for years. Batteries last forever in it. Cheap enough to keep a spare in my laptop bag for when I need to travel for work. Not a gaming mouse, but a serviceable work mouse. But not tiny like a "travel mouse" so it isn't uncomfortable to use. A man can use one without his hand cramping up.
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Reviewed in the United States on May 12, 2026
★★★★★ 5
Comfortable Seating
Color: Black, Style: Classic
I honestly didn’t expect this chair to be this comfortable, but it has exceeded my expectations in every way. I sit at my desk for long hours every day, and the adjustable air-pump lumbar support has been a total game changer. I love that I can fine-tune the firmness depending on how my back feels that day. My lower back pain has noticeably improved since switching to this chair.The seat is wide, thick, and very supportive without feeling stiff, which makes long work sessions much more comfortable. The armrests are another big plus—they adjust in so many directions that I can always find the perfect position for typing, reading, or relaxing. The chair feels extremely sturdy and well built, and it gives me confidence knowing it supports higher weight without wobbling.Assembly was straightforward and took about 20 minutes. Overall, this chair feels premium, comfortable, and thoughtfully designed. I would absolutely recommend it to anyone looking for a reliable, all-day office chair.
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Reviewed in the United States on March 28, 2026
★★★★★ 5
Nice chair, w/ good cust support
Color: Black, Style: Classic
I apologize for length, but if I am doing a review for other people I assume you want to have as
much info as possible to make a decision. I feel this chair is for tall/fat/both so will review it as
such. At 6’4” @ 350lbs I fit into both, but reviewing based upon my body, yours is different so
adjust according.
TLDR – Would buy again, cavernous comfy chair with excellent customer support. Only
personal dings against chair are the back could be taller, but added back due to support.
Parts + Fit/Finish + Assembly:
The parts have some heft and feel solid as expected for a chair designed for heavy people.
Material and stitching look proper and I see no flaws. My box was beat to hell and ripped
opened at one point. Packing material took the hit and did its job as the items were unaffected.
The gas cylinder for the chair was missing and assume lost during shipping. (see customer
service). Assembly was standard office chair fare with simple and clear instructions.
Wheels / Height / Controls:
I normally wouldn’t think of mentioning wheels, but it’s different than expected. They are
good, maybe too good. A slight kick to push you back on wood floors sends you flying. The
height adjustment for me is good/standard. At full height my feet are flat on the floor and
where I would have the chair even if it went higher. My wife (5’6”) at that height is about 2.5
inches above the floor. Taller people than myself may wish for more height. Chair controls are
standard fare and operate smoothly
Seat:
It’s large and with the arms is there is nothing even close to your hip/legs. I can put my fist on
my hips and my arms barely touch the chair arms. This is why you are thinking of this chair, and
for that you will not be disappointed. The seat is not pillow soft and IMHO a little firmer than I
liked at first, but after a few days got broken in or I adjusted. I am a programmer + gamer so
spend a lot of time in the chair for hours on end. Comfortable and no complaints at all. Seat
depth for me is ~1” from my knee and good with roughly 20.5” usable butt/thigh length. That
should be fine for big/tall but may be a bit much for big/short. Measure your current chair and
decide from there.
Back:
The back lets the chair down a bit for me, the big/tall user, as the target seems to be big/short
users. The back ends just below my shoulder-line. That obviously means no leaning my head
back and the headrest is squarely on my shoulder blades. Not uncomfortable, but I’d prefer a
taller back. For me personally I’d like it to be extended 4”, but that would likely be an issue for
shorter users. I feel if the manufacturer increased the back by 2 inches it would be an ideal
compromise for all users. The chair has an inflatable lumbar support, which I did not use as I
personally find those uncomfortable. Also note the chair is designed for a more proper posture
with a 90deg back and not a more relaxed 100-110deg. Neither pro/con as personal
preference.
Arms:
The design of the arms being supported by rear only as mentioned earlier allow for an
abundance of hip/thigh space. This is an excellent ergonomic design with a potential caveat.
More stress will be placed upon the connection/joint. The joint for this chair is just shy of 4” so
seems beefy but only time will tell if it holds up to the lateral force of leaning on it while
reading. My chairs tend to last 5-7 years, due to the right arm feeling wobbly or the chair
leaning to the right. The arm adjustments provide a nice front/back of ~3”, from touching chair
back to 3” gap between chair/armrest. The height is similar and also moves the armrest
forward about another 2”. At full forward/up the armrest are higher than I like so should easily
accommodate taller users.
Customer Service
My chair was missing a part that I suspect was lost during shipping due to box condition. I
contacted them Sun (7/20/2025 @ 1201). At 2228 that night I received a response that they
acknowledged the issue and gave a tracking order for the missing part. The part arrived Mon
7/28 and gave a few days to test it out for review Fri (8/1). Obviously you don’t want an issue,
but if an issue arises how a company handles it tells you a lot IMHO on how they feel about
their product. I am very pleased with their handling of the matter.
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Reviewed in the United States on August 4, 2025
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