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Description
CD45RA His Tag Protein, HumanProduct Specification Species Human Synonyms B220, CD45, CD45R, GP180, IMD105, L CA, LCA, LY5, T200,PTPRC Accession P08575 8 Amino Acid Sequence Gln26 Lys482, with C terminal His Expression System HEK293 Molecular Weight 90 130kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size
Product Specification
| Species | Human |
| Synonyms | B220, CD45, CD45R, GP180, IMD105, L-CA, LCA, LY5, T200,PTPRC |
| Accession | P08575-8 |
| Amino Acid Sequence | Gln26-Lys482, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 90-130kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Anderson, J.N. et al. (2004) FASEB J. 18:8. 2.Streuli, M. et al. (1987) J. Exp. Med. 166:1548. 3.Hermiston, M.L. et al. (2003) Annu. Rev. Immunol. 21:107. |
Background
Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin.Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
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