S-RMab® PD-L1 Recombinant Rabbit mAb (SDT-119-286)
SKU: 86493030610

S-RMab® PD-L1 Recombinant Rabbit mAb (SDT-119-286)

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Description

S-RMab® PD-L1 Recombinant Rabbit mAb (SDT-119-286)Product Specification Host Rabbit Antigen PD L1 Synonyms Programmed cell death 1 ligand 1, PDCD1 ligand 1, Programmed death ligand 1, hPD L1, B7 homolog 1, B7 H1, CD274, B7H1, PDCD1L1, PDCD1LG1 Immunogen Recombinant Protein Location Cell membrane Accession Q9NZQ7 Clone Number SDT 119 286 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen PD-L1
Synonyms Programmed cell death 1 ligand 1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1
Immunogen Recombinant Protein
Location Cell membrane
Accession Q9NZQ7
Clone Number SDT-119-286
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 null
IHC-P 1:100 null

Background

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.

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SKU: 86493030610

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4.2 ★★★★★
Based on 2329 reviews
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Product Reviews
J
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Jay
Draper, US
★★★★★ 3
Difficult to grasp
Format: Hardcover
I love the aspects of career counseling. But this book makes the theories hard to understand.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 20, 2018
K
Verified Purchase
Kelley Chantelle Hurley
Bozeman, US
★★★★★ 5
Good
Format: Hardcover
Was great quality
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 8, 2021
D
Verified Purchase
David
Boise, US
★★★★★ 5
High energy mindset book, but very repetitive
Format: Hardcover
The 10X Rule is a very high energy, motivational book focused on taking massive action and setting goals much higher than what most people think is realistic. The strongest part is the mindset shift. It constantly pushes the idea that success requires way more effort, persistence, and volume than people typically expect. If you are looking for motivation to work harder and avoid playing it safe, the message definitely hits. It also does a good job challenging excuses and comfort zones. The tone is very direct and intense, which can be useful if you respond well to that style of motivation. However, the book is very repetitive. The same core idea of “10X effort” is repeated throughout almost every section in slightly different ways, which can make it feel stretched out. It is more motivational than practical, so if you are looking for step-by-step systems or structured strategies, this may not be what you are expecting. Overall, it’s a strong mindset book if you want intensity and motivation, but less useful if you are looking for detailed execution plans.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 13, 2026
F
Verified Purchase
Fernando Ramos
Whiting, US
★★★★★ 5
An Excellent, Eye-Opening Read That Truly Makes You Reflect
Format: Kindle
The 10X rule is an excellent book—engaging, interactive, and surprisingly eye-opening. It doesn’t just present ideas; it invites you to actively reflect on your own behavior, decisions, and patterns. As you move through the chapters, you’re constantly prompted to pause, think, and reassess the way you act and respond in everyday situations.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 8, 2026
S
Verified Purchase
Shawn K. Manaher
Alexandria, US
★★★★★ 5
Grant Doesn't Hold Back!
Format: Hardcover
What It's All About... So, the 10 X Rule is a very motivation book about rethinking the way you think about goal setting and the effort it takes to accomplish your goals. Without giving away the obvious, Grant shares that when we go for a goal like, "I want $100 in the next 30 days to pay my bills." We often fall short of that goal and need to restate it as: "I want $1,000 in the next 30 days to pay my bills." Now, if you do far short (happens often), you will still hit somewhere greater than $100. Therefore, we must always 10 X our goals to hit the goals we desire. Now, when it comes to effort, because we often underestimate the action it takes to meet our goals... Our new $1,000 goal requires 10 X effort to hit it. So, if you think "To hit $1,000, I need to make 1 sales call each day." you need to 10 X that number and make 10 sales calls to hit your new $1,000 goal. Therefore, we must always 10 X our effort and change our actions to meet out goals. He also takes times at the end of the book to outline 32 characteristics of successful people that also help in accomplishing these 10 X Goals. Some of those include: Have a "Can Do" attitude, Seek to Solve Problems, Focus on Now, Be Highly Ethical, etc. At the end of each chapter he asks a set of questions that helps to reinforce the material you just read. My Take... Overall, this really juiced me up and got me to rethink the way in which I look at goals and the actions I need to meet them. When reading such a book, I often get so inspired that I shoot off goals without really appreciating the amount of effort it will take to hit them. I walked away from Grant's book with a firm idea on the big goals I want to hit and a healthier understanding of what it's going to take to get there. The overall feel of the book was also inspiring because Grant is the type of person that believes in going for goals, even if you don't know exactly how you are going to accomplish them... Just get started. I resonate with that line of thinking. If you like listening to audio books, Grant does his own reading of the book, which gives a greater sense of emphasis and passion behind the content. Who should read this... Entrepreneurs, Business owners, High School and College Students WARNING: There is some cursing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2016

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